Monday, November 7, 2011
Kanamycin and neomycin are related to streptomycin but differ from it in that resistant organisms are slow to appear. Kanamycin is less toxic than neomycin and can be given parent rally. It should be reserved for the treatment, in hospital of serious infections such as peritonitis or septicaemia due to Esch. As with streptomycin there is a risk of damage to the eighth nerve especially in the elderly or if renal function is impaired. The dose should not exceed 1 giddily. Neomycin is too toxic to be given parent rally, but as it very rarely causes allergic reactions and as bacterial resistance to it seldom develops, ointments containing neomycin are extensively used in infections of the skin. As neomycin is poorly absorbed it can be given by mouth in the treatment of intestinal infections and for the sterilization of the bowel pre-operatively or in the management of hepatic coma.
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